{"id":17722,"date":"2022-11-16T16:19:00","date_gmt":"2022-11-16T13:19:00","guid":{"rendered":"https:\/\/www.khas.edu.tr\/events\/molekuler-biyoloji-ve-genetik-seminerleri-dr-thomas-wytock\/"},"modified":"2025-04-17T16:22:50","modified_gmt":"2025-04-17T13:22:50","slug":"molekuler-biyoloji-ve-genetik-seminerleri-dr-thomas-wytock","status":"publish","type":"etkinlik","link":"https:\/\/www.khas.edu.tr\/en\/events\/molekuler-biyoloji-ve-genetik-seminerleri-dr-thomas-wytock\/","title":{"rendered":"Molek\u00fcler Biyoloji ve Genetik Seminerleri: Dr. Thomas Wytock"},"content":{"rendered":"\n<p>Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fcm\u00fcz\u00fcn organize etti\u011fi seminer serisinin yeni konu\u011fu, Northwestern University\u2019den\u00a0<strong>Dr. Thomas Wytock<\/strong>\u00a0olacak.<\/p>\n\n<p>Dr. Wytock\u2019\u0131n\u00a0<strong>\u201cInferring phenotype from \u2018omics data using machine learning\u201d\u00a0<\/strong>ba\u015fl\u0131kl\u0131 konu\u015fmas\u0131n\u0131 17 Ekim Per\u015fembe saat 16:00\u2019dan itibaren Zoom\u2019dan takip edebilirsiniz.<\/p>\n\n<p>The event is in English.<\/p>\n\n<p><strong>Zoom ID:<\/strong>\u00a0839 7010 6851<\/p>\n\n<p><strong>\u00d6zet:\u00a0<\/strong>Repositories of \u2018omics data continue to expand at an exponential rate, raising the possibility of a comprehensive understanding of cellular function. Cellular phenotypes such as doubling time in single-cell organisms and cell type in humans arise from the collective interaction of myriad proteins, nucleic acids, and metabolites, but divining the specific interactions that mediate a phenotype of interest remains an open question. In this talk, I will describe our approach that uses datasets of thousands of \u2018omics measurements to train a supervised\u00a0<em>k<\/em>-nearest neighbors (KNN) model that predicts growth rate in microorganisms and cell type in humans with over 80% and 90% accuracy, respectively. Our approach learns which eigenvectors of the gene correlation matrix best describe the phenotype of interest, thereby taking advantage of the multi-scale structure of cellular function. Once trained, the KNN model maps an arbitrary gene expression state to a given phenotype, making it a tool suitable for metabolic engineering, drug discovery, and cell reprogramming.<\/p>\n\n<p><strong>Konu\u015fmac\u0131 Hakk\u0131nda:\u00a0<\/strong>I am a Postdoctoral Fellow at Northwestern in Adilson Motter\u2019s group, where I also completed my Ph. D. in Physics. My research interests include complex systems, nonlinear dynamics, bioinformatics, and computational biology. My research goals are (1) to take broad theoretical concepts from physics, network science, and nonlinear dynamics and use these to address problems of collective behavior in biology and (2) to develop methods that facilitate the holistic interpretation of \u2018omics data to generate hypotheses.<\/p>\n","protected":false},"featured_media":17721,"template":"","meta":{"slim_seo":{"title":"Molek\u00fcler Biyoloji ve Genetik Seminerleri: Dr. Thomas Wytock - Kadir Has University","description":"Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fcm\u00fcz\u00fcn organize etti\u011fi seminer serisinin yeni konu\u011fu, Northwestern University\u2019den\u00a0 Dr. Thomas Wytock \u00a0olacak. Dr. Wytock\u2019\u0131n\u00a0"}},"birimler":[68],"class_list":["post-17722","etkinlik","type-etkinlik","status-publish","has-post-thumbnail","hentry","birimler-mbg"],"_links":{"self":[{"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/etkinlik\/17722","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/etkinlik"}],"about":[{"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/types\/etkinlik"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/media\/17721"}],"wp:attachment":[{"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/media?parent=17722"}],"wp:term":[{"taxonomy":"birimler","embeddable":true,"href":"https:\/\/www.khas.edu.tr\/en\/wp-json\/wp\/v2\/birimler?post=17722"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}