{"id":17697,"date":"2023-03-16T17:04:00","date_gmt":"2023-03-16T14:04:00","guid":{"rendered":"https:\/\/www.khas.edu.tr\/events\/molekuler-biyoloji-ve-genetik-seminerleri-prof-tugba-bagci-onder\/"},"modified":"2025-04-17T15:47:33","modified_gmt":"2025-04-17T12:47:33","slug":"molekuler-biyoloji-ve-genetik-seminerleri-prof-tugba-bagci-onder","status":"publish","type":"etkinlik","link":"https:\/\/www.khas.edu.tr\/en\/events\/molekuler-biyoloji-ve-genetik-seminerleri-prof-tugba-bagci-onder\/","title":{"rendered":"Molek\u00fcler Biyoloji ve Genetik Seminerleri: Prof. Tu\u011fba Ba\u011fc\u0131 \u00d6nder"},"content":{"rendered":"\n<p>Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fcm\u00fcz\u00fcn organize etti\u011fi seminer serisinin yeni konu\u011fu, Ko\u00e7 \u00dcniversitesi T\u0131p Fak\u00fcltesi&#8217;nden <strong>Prof. Tu\u011fba Ba\u011fc\u0131 \u00d6nder <\/strong>olacak.<\/p>\n\n<p>Prof. \u00d6nder&#8217;in <strong>\u201c<\/strong><strong>Exploiting Epigenetic Vulnerabilities of Cancer Cells to Overcome Therapy Resistance<\/strong><strong>\u201d\u00a0<\/strong>ba\u015fl\u0131kl\u0131 konu\u015fmas\u0131n\u0131 16 Mart Per\u015fembe saat 16:00\u2019dan itibaren Zoom \u00fczerinden takip edebilirsiniz.<\/p>\n\n<p>The event is in English.<\/p>\n\n<p><strong>Zoom ID: <a href=\"https:\/\/us02web.zoom.us\/j\/82866955721?pwd=U3dOa3lQWUNGZklnd0N1UUNDM1QzUT09\">828 6695 5721<\/a><\/strong><\/p>\n\n<p><strong>\u00d6zet: <\/strong>A mechanism of therapy resistance is transcriptional dysregulation of cell death and survival-related genes. Changes in the epigenome are thought to play a critical role in acquired therapy resistance. Epigenetic modifications occur on chromatin and consist mainly of DNA methylation, histone acetylation and methylation, governed by the activity of several chromatin-modifying proteins. To decipher the relationship between therapy response and epigenetics, we undertake loss-of-function approach and interrogate the roles of chromatin modifying proteins with functional screens. These screens are based on genetic or chemical ablation of protein functions. In the first one, we use shRNA or CRISPR\/Cas9-based libraries, in the second one we use chemical probes to discover novel molecular mechanisms to overcome therapy resistance. We utilize next generation sequencing to profile and map the differences between drug-sensitive and drug-resistant populations of cancer cells, that we generate in our laboratory. This talk will give an overview of our current approaches and highlight the roles of our recently identified molecular mechanisms.<\/p>\n\n<p><strong>Konu\u015fmac\u0131 Hakk\u0131nda: <\/strong>Prof. Tu\u011fba Ba\u011fc\u0131 \u00d6nder graduated from the Department of Molecular Biology and Genetics, Bilkent University in 2002. She then earned her Ph.D. degree in Neuroscience at Sackler School of Graduate Biomedical Sciences at Tufts University in 2008. She pursued her postdoctoral work at Harvard Medical School, Massachusetts General Hospital on the development of tumor-specific pro-apoptotic therapies in animal models of brain cancer. In 2012, she joined Ko\u00e7 University School of Medicine and established the Brain Cancer Research and Therapy Laboratory. Her research group is currently working on the understanding of epigenetic regulation of cell death, therapy resistance and progression of cancers. Her work is supported by FP7 Programme-Marie Curie Career Integration Grant, T\u00dcB\u0130TAK, TUSEB, Royal Society-UK and Ko\u00e7 University Research Center for Translational Medicine (KUTTAM). Prof. Ba\u011fc\u0131 \u00d6nder is also a recipient of Barbara Talamo Trainee (2008), UNESCO-L\u2019oreal Women in Science (2013), BAGEP (2014), Sedat Simavi Heath Sciences (2021) and International Cell Death Society Rising Women in Science (2022) awards.<\/p>\n\n<p><\/p>\n","protected":false},"featured_media":12572,"template":"","meta":{"slim_seo":{"title":"Molek\u00fcler Biyoloji ve Genetik Seminerleri: Prof. Tu\u011fba Ba\u011fc\u0131 \u00d6nder - Kadir Has University","description":"Molek\u00fcler Biyoloji ve Genetik B\u00f6l\u00fcm\u00fcm\u00fcz\u00fcn organize etti\u011fi seminer serisinin yeni konu\u011fu, Ko\u00e7 \u00dcniversitesi T\u0131p Fak\u00fcltesi'nden Prof. Tu\u011fba Ba\u011fc\u0131 \u00d6nder olacak. 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