Yakın zamanda bölümümüzden çıkan yayınlar:

Katarina Nikolic, Lazaros Mavridis, Teodora Djikic, Jelica Vucicevic, Danica Agbaba, KemalYelekci andJohnB.O.Mitchell. “Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies”  http://dx.doi.org/10.3389/fnins.2016.00265. Front. Neurosci., 10 June 2016

- Ozgur O, Doruker P, Akten ED,  “Investigation of Allosteric Coupling in Human β2-adrenergic Receptor in the Presence of Intracellular Loop 3”, submitted to BMC Structural Biology. (2016)

-  Ozyigit I, Akten ED, Pekcan O, “Structural Analysis of Peptide Fragments Following the Hydrolysis of Bovine Serum Albumin by Trypsin and Chymotrypsin”, Journal of Biomolecular Structure & Dynamics, Vol:34, No:5, pg:1092-1100 (2016)

Sahin HB, Karatas OF, Specchia V, Tommaso SD, Diebold C, Bozzetti MP, Giangrande A.” Novel Mutants of the Aubergine Gene.” Fly (Austin). Apr 11:0. (2016)

- İ. E. Özyiğit D. Akyön and Ö. Pekcan “Structural Analysis of Peptite Fragments Following the Hydrolises of Bovine Serum Albumine by Tripsin and Chymotripsin” J. Biomolecular Structure and Dynamics, 34(5), 1092-1100 (2016)

- İ. E. Özyiğit, E. Karakuş and Ö. Pekcan “The Modifier Effects of Trypsin and Chymotrypsin on Fluorescence Life Time Disdribution of “N-(Pyrenyl) melamide- Bovine Serum Albumin” Complex” Spectro-chimica Acta , Part A Molecular and Biomolecularspectra, 154,8-12 (2016)

-  Abekhoukh S, Sahin HB, Grossi M, Zongaro S, Madrigal I, Kazue-Sugioka D, Raas-Rothschild A, Doulazmi M, Carrera P, Stachon A, Scherer S, Drula do nascimento MR, Trembleau A, Arroyo I, Szatmari P, Smith IM, Milà M, Smith AC, Giangrande A, Caillé I, Bardoni B. “New Insights into the Regulatory Function of CYFIP1 in the Context of WAVE- and FMRP-Containing Complexes” Submitted to Plos Genetics (2016)

- Evranos-Aksöz B, Baysal İ, Yabanoğlu-Çiftçi S, Djikic T, Yelekçi K, Uçar G, Ertan R. "Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives". Arch Pharm (Weinheim). 2015 Oct;348(10):743-56. doi: 10.1002/ardp.201500212. Epub 2015 Aug 21. (2015)

-  Kurkcuoglu Z, Findik D, Akten ED, Doruker P, “How an inhibitor bound to subunit interface alters triosephosphate isomerase dynamics”, Biophysical J, Vol:109, pp:1169-1178 (2015)

-  Koroglu A, Akten ED, “Transmembrane helix 6 observed at the interface of β2AR homodimers in blind docking studies“, Journal of Biomolecular Structure & Dynamics, Vol:33(7), pp:1503-1515 (2015)

-  F. Pinar Turkmenoglu, İpek Baysal, Samiye Ciftci-Yabanoglu, Kemal Yelekci,  Hamdi Temel, Salih Paşa, Nurten Ezer, İhsan Çalış and Gulberk Ucar., “Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol.Molecules Journal,. 20(5), 7454-7473; doi:10.3390/molecules20057454 (2015)

- Kemal Yelekci, Bahanur Örtmen., “De Novo Design of Potent and Selective Neuronal Nitric Oxide Synthase (nNOS) Inhibitors by a Fragment-Based Approach“, Journal of Pharmaceutical Chemistry, ISSN: 2349-5731 (2015)

- Malcomson T, Yelekci K, Mar Borrello MT, Ganesan A, Semina E, De Kimpe R, Mangelinckx S, Ramsay RR.,  “cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases”,  FEBS Journal, DOI: 10.1111/febs.13260, (2015).

- Bennion B.J.*, Essiz S.G.*, Lau E.Y, Fattebert,J.C., Emigh A. , Lightstone, F.C, A wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulations, PLoS ONE 10(4) (2015) *contributed equally

- Maria Pia Bozzetti, Valeria Specchia, Pierre Cattenoz, Pietro Laneve, Annamaria Geusa, H. Bahar Sahin, Silvia Di Tommaso, Antonella Frisicini, Serafina Massari, Celine Diebold, and Angela Giangrande. “The Drosophila Fragile X Mental Retardation Protein participates in the piRNA pathway”. The Journal of Cell Science. April (2015).

- Z. Doğruyol, N. Arsu, S. Keskin Doğruyol and Ö. Pekcan “Percolation of Glassy Regions during Polymerization of Epoxy Acrylate in Dimethylformamide” Prog. Org.  Coat. 80, 59-64 (2015)

- G. Evingür and Ö. Pekcan “Universality of Elasticity in PAAm-PNIPA Copolymer” European Physical Journal App. Phys. 69, 11201 (2015)

- G. Evingür and Ö. Pekcan “Kinetical Models for the Dynamical Behaviour of PAAM-Kappa Carrageenan Composites”  Biological Physics, 41, 37-47 (2015)

- S. Kara, E. Arda, O. Bahadır Mergen and Ö. Pekcan “Comparison of Fluoescence and UV-Visible Spectroscopic Techniques for Thermal Phase Transitions of Agarose Gels” Polym. Bull. 72, 157 (2015)

- Ş. Uğur, M.S. Sunay and Ö. Pekcan “Fluorescence Study of the Effects of Particle Size in PS/ Al2O3 Nanocomposites Films” Plastic, Rubber and Composites 44,4,129-141 (2015)

- A.H. Bilge and Ö.Pekcan “A Mathematical Characterization of the Gel Point in Sol-Gel Transition” Journal of Physics 574, 012005 (2015)

- Ö. Yargı, Ö. Pekcan and Ş. Uğur “Measurement of Oxygen Diffusion in PS/PNIPAM Composites Films Using Fluorescence Quenching” Plastic, Rubber and Composites 44, 4,189 (2015)

- G. Evingür and Ö. Pekcan “Elasticity Study of PAAm- Kappa Carrageenan Composites prepared in various Kappa Carrageenan Content and Measured at Several Temperatures” Acta Physica Polanica, 128,3 331 (2015)

- Ş.Uğur, M.S. Sunay, and Ö. Pekcan “Fluorescence Study of the film Formation from PS Latex-TiO2 Composite; Effects of TiO2 Content, Film Thickness and Particle Size” Journal of Colloid Science and Biotechnology 4 (2), 117-132 (2015)

- C. Özen, Y. Alhassid and H. Nakada, “Nuclear state densities of odd-mass heavy nuclei in the shell model Monte Carlo approach”, Phys. Rev. C 91 (2015) 034329 (2015)

- Y. Alhassid, M. Bonett-Matiz, A. Mukherjee , H. Nakada and C. Özen, “Recent Advances in the Application of the Shell Model Monte Carlo Approach to Nuclei”, J. Phys. Conf. Ser., 580 (2015) 012009. (2015)

- C. Özen, Y. Alhassid, and H. Nakada, “Collective Enhancement of Nuclear State Densities by the Shell Model Monte Carlo Approach”, J. Phys. Conf. Ser., 590 (2015) 012025. (2015)

- Evranos-Aksöz B, Yabanoğlu-Çiftçi S, Uçar G, Yelekçi K, Ertan R. “Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies.Bioorg Med Chem Lett. 2014. 1;24(15):3278-84. (DOI: 10.1016/j.bmcl.2014.06.015) (2014)

- Yakar R, Akten ED, “Discovery of high affinity ligands for beta2 adrenergic receptor through pharmacophore-based high-throughput virtual screening and docking“. J Molecular Graphics & Modelling, Vol: 53, 148-160 (2014).

- M.S. Sunay,M. Rahman, A.Elaissari and Ö. Pekcan, Ş.Uğur “Spectroscopic study of film formation  from PS Latex/TiO2 Nanocomposites Prepared by Dip-Coating Method” Polym. Eng. Sci. 54,288-302 (2014)

- Ö. Yargı, Ş. Uğur and Ö.Pekcan “Polymer/Carbon Nanotube Composite Film formation; A fluorescence Study”  Polymer Composites, 35, 817 (2014)

- H. Kaygusuz, B. Erim, Ö. Pekcan and G. Evingür “Cation Effect on Slow Release From Alginate Beats; A Fluorescence Study” J . Fluorescence , 2, 161 (2014)

- Ş.Uğur,M.S. Sunay, and Ö. Pekcan “Study of Film formation from PS Latex/TiO2 Nanocomposites;Effect of Latex Size and TiO2 Content” Polymer Composites , 35, 2376 (2014)

- Ö. Pekcan Ş.Uğur, M.S. Sunay, “ Fluorescence Study of film formation  from PS / Al2O2 Nanocomposites” Progress in Organic Coatings , 77,1554 (2014)

- C. Saçlıoğlu, Ö Pekcan and V. Nanjundiah “Gruop Behaviour in Physical Chemical and Biological Systems”  J. Bio. Sciences, 39,2,  177- 189 April (2014)

- G. Evingür,  Hakan, B. Erim and Ö. Pekcan “Gelation of PAAm-PVP Composites;  A Fluorescence Study” Int. J. Mod. Phys. B 28,1450122 (2014)

- G. Evingür,  H. Kaygusuz, B. Erim and Ö. Pekcan “The Effect of Calcium Ion  Concentration on Small Molecule Desorption from  Alginat Beats ” J. Macromolecular Sci. Part B, 53,1157 (2014)

- G. Evingür and Ö. Pekcan “The Effect of MWNT on the Behaviour of Swelling in PAAm-MWNT Composites” J. Reinforced Plastic and Composites 33(13)1199 (2014)

- G. Evingür and Ö. Pekcan “Elastic Properties of a Swollen PAAm-PNIPA Coplymer with Various NIPA Content”  Polymer. Plastic Technology and Engineering, 53,834-839 (2014)

-  C. Özen and N.T. Zinner, “Mapping the Two-Component Atomic Fermi Gas to the Nuclear Shell Model”, J. Eur. Phys. D 68 (2014) 225. (2014)

-  Y. Alhassid, C. Özen and H. Nakada, "Calculating Level Densities of Heavy Nuclei by the Shell Model Monte Carlo Method", Nucl. Data Sheets 118 (2014) 233. (2014)

Kemal Yelekçi, Bora Büyüktürk, Nurdan Kayrak, “In silico identification of novel and selective monoamine oxidase B inhibitors”. J Neural Transm 2013. 120:853–858, (DOI 10.1007/s00702-012-0954-0) (2013)

-  Umut Salgın-Gökşen, Nesrin Gökhan-Kelekçi, Samiye Yabanoğlu-Çiftçi, Kemal Yelekçi, Gülberk Uçar, “Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives”. J Neural Transm . 2013. 120:883–891, (DOI 10.1007/s00702-013-0968-2) (2013)

-  Umut Salgın-Gökşen, Samiye Yabanoğlu-Çiftçi, Ayşe Ercan, Kemal Yelekçi, Gülberk Uçar, Nesrin Gökhan-Kelekçi, “Evaluation of selective human MAO inhibitory activities of some novel pyrazoline derivatives”. J Neural Transm, 2013. 120:863–873, (DOI 10.1007/s00702-013-0980-6). (2013)

- Safiye Sağ Erdem, Seyhan Türkkan, Kemal Yelekçi, Nesrin Gökhan-Kelekçi, “Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: docking and quantum chemical calculations”. J Neural Transm, 2013. 120:859–862,   (DOI 10.1007/s00702-012-0950-4) (2013).

-  Ozcan O, Uyar A, Doruker P, Akten ED, “Effect of intracellular loop 3 on intrinsic dynamics of human beta-2 adrenergic receptor”. BMC Structural Biology, Vol:13, 29 (2013).

- Cakan S, Akdoğan ED, “Exploring distinct binding site regions of beta-2 adrenergic receptor via coarse-grained molecular dynamics simulations”. Turkish Journal of Chemistry, Vol:35, 449-463 (2013).

-  Koziol L., Essiz S.G., Wong S, Lau E.Y., Valdez C., Satcher J.H., Aines R.D., Lightstone F. “Computational analysis of a Zn-bound tris(imidazolyl) calix[6]arene aqua complex: toward incorporating the second-coordination sphere into carbonic anhydrase biomimetics”. J. Chem. Theory Comput., 9, 1320 (2013)

- E. Arda, S.Kara and Ö. Pekcan “Electrical Optical and Fluorescence Percolation in PVAc-BuA/ MWCNT Composite Films” Phase Transitions 86 (2013)

- Ö. Yargı, Ş. Uğur and Ö. Pekcan “Oxygen Diffusion into MWCNT doped PS Latex Film Using Fluorescence Technique” J. Fluorescence 23,357-366 (2013)

- A. H. Bilge, Ö. Pekcan “Mathematical Description of the Critical Point in Phase Transitions” Int. J. Modern Phys. 24(10) 350065(1-9) (2013)

- G. Evingür and Ö Pekcan “Superelastic Percolation Network of PAAm- Kappa Carrageenan Composites” Cellulose 20, 1145-1151 (2013)

-  C. Özen, Y. Alhassid and H. Nakada, “The crossover from vibrational to rotational collectivity in heavy nuclei in the shell-model Monte Carlo approach”, Phys. Rev. Lett. 110 (2013) 042502. (2013)

-  E. İşeri and C. Özen, “Turkey’s nuclear energy policy: towards a sustainable energy mix?”, Int. J. Nuclear Governance, Economy and Ecology, Vol. 4, No. 1 (2013) 41. (2013)

-  Cifci G, Aviyente V, Akten ED, “Molecular Docking Study Based on Pharmacophore Modeling for Novel PhosphodiesteraseIV Inhibitors”. Molecular Informatics, Vol:31(6-7), pp:459-471 (2012)

-  Y. Alhassid, A. Mukherjee, H. Nakada and C. Özen, “Recent developments in the shell model Monte Carlo approach to nuclei", J. Phys. Conf. Ser. 403 (2012) 012012. (2012)

-  Gamze Bora Tatar, Tenzile Deniz Tokluman, Kemal Yelekçi, Hayat Yurter,“Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design”. Turk J Chem, 35 . 2011. 861 – 870. (doi:10.3906/kim-1107-34) (2011).

Ebru Demet Akdoğan, Burak Erman, Kemal Yelekçi. “In silico design of novel and highly selective lysine-specific histone demethylase inhibitors”. Turk J Chem 35. 2011. 523-542, (doi:10.3906/kim-1102-985) (2011).

-  Kurkcuoglu Z., Ural G., Akten ED, Doruker P. “Blind Docking of Benzothiazoles to Multiple Receptor Conformations of Triosephosphate Isomerase from Trypanosoma cruzi and Human”. Molecular Informatics, Vol:30, pp:986-995 (2011)

-  Galy A*, Schenck A*, Sahin HB*, Qurashi A, Sahel JA, Diebold C, Giangrande A. “CYFIP dependent actin remodeling controls specific aspects of Drosophila eye morphogenesis”. Developmental Biology, 2011 Nov 1;359(1):37-46. Epub Aug 22 (2011). Co-first author.

-  Nesrin Gökhan-Kelekçi, Ö. Özgün Şimşek, Ayşe Ercan, Kemal Yelekçi, Z. Sibel Şahin Şamil Işık, Gülberk Uçar, A. Altan Bilgin. “Synthesis and molecular modeling of some novel hexahydroindazole derivatives as “potent monoamine oxidase inhibitors”. Bioorganic & Medicinal Chemistry. 2009, 17(4), 5219-5228. (2009)

-  Gamze Bora-Tatar, Didem Dayangaç-Erden, Ayhan S. Demir, Sevim Dalkar, Kemal Yelekçi, Hayat Erdem-Yurter, “Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies”. Bioorganic & Medicinal Chemistry. 2009. 17(18), 6761-6772. (2009)

-  Didem Dayangaç-Erden, Gamze Bora, Peruze Ayhan, Çetin Kocaefe, Sevim Dalkara, Kemal Yelekçi, Ayhan S. Demir, Hayat Erdem-Yurter, “Histone Deacetylase Inhibition Activity and Molecular Docking of (E )-Resveratrol: its Therapeutic Potential in Spinal Muscular Atrophy”. Chemical Biology & Drug Design. 2009, 37(3), 355-364. (2009).

-  Nesrin Gökhan-Kelekçi, Semra Koyunoğlu, Samiye Yabanoğlu, Kemal Yelekçi, Özen Özgen, Gulberk Uçar, Kevser Erol, Engin Kendi, Akgul Yeşilada,”New Pyrazoline Bearing 4(3H)-quinazolinone Inhibitors of Monoamine Oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity“. Bioorganic & MedicinalChemistry. 2009. 17(2), 675-689. (2009)

Akten, ED, Cansu S and Doruker P, “A Docking Study Using Atomistic Conformers Generated via Elastic Network Model for Cyclosporin A/Cyclophilin A Complex”. Journal of Biomolecular Structure & Dynamics, Vol:27(1), pp:13-25 (2009)

Essiz S. G. and R. D. Coalson, “Dynamical Linear Response Theory for Conformational Relaxation of Proteins”. J. Phys. Chem. B, 113, 10859 (2009)